雪山飞狐

Dye-Coated Retinal Prosthesis Shows Promise for Restoring Vision
March 17, 2015
Researchers at Okayama University in Japan are planning to launch a clinical trial later this year for an innovatively simple retinal prosthesis they’ve developed to restore vision in people blind from retinitis pigmentosa (RP) and related conditions. Known as the Okayama University-type retinal prosthesis, or OUReP, it’s a plastic film coated with a light-sensitive dye that is implanted beneath the retina. In a lab study, the device preserved vision in rodents with advanced RP. The investigators published the study’s results in the Journal of Artificial Organs.
Often referred to as artificial or bionic retinas, prostheses are designed to replace photoreceptors, the cells in the retina that process light and make vision possible. People blind from advanced retinal diseases have lost most or all of their photoreceptors.
Most retinal prosthetic technologies, including the Argus II and the Alpha IMS, use video cameras to capture images. An array of electrodes, implanted adjacent to the retina, then convert the images into electrical signals, which are sent to the brain, where they’re interpreted as vision.
The OUReP is much simpler. There is no camera or electrodes, and it does not need an electrical current, which usually requires an external power source. Instead, the dye on the film captures light coming into the eye and stimulates surviving retinal neurons, including ganglion and bipolar cells, to send visual information back to the brain.
Toshihiko Matsuo, M.D., Ph.D., the lead investigator on the project, says implanting the OUReP beneath the retina should be relatively straightforward in humans. “The sheet can be implanted in the subretinal space, using surgical methods established more than 20 years ago,” he explains. “Therefore, the implantation procedure should be technically feasible for vitreoretinal surgeons.”
He adds that the prosthesis’ polyethylene film has been used safely in other medical implants for humans, and the dye has not shown any toxicity in testing thus far.
In addition to preserving vision, the OUReP appears to reduce the loss of retinal cells in the rodents, suggesting that the dye may be protective. However, the investigators caution that more research is needed to better understand the effect.

雪山飞狐

Dye-Coated视网膜假体显示恢复视力的承诺
2015年3月17日
研究人员日本冈山大学在日本正计划今年晚些时候推出一个临床试验的创新简单视网膜假体他们发达失明者能恢复视力色素性视网膜炎(RP)及相关条件。 被称为日本冈山大学生视网膜假体,或者OUReP,这是一个塑料薄膜涂有感光染料,视网膜下植入。 在实验室研究中,该设备保存视力与先进的RP啮齿动物。 研究人员的研究结果发表《人造器官。
通常被称为人工或仿生视网膜假体的设计来取代光感受器在视网膜细胞,过程光和使愿景成为可能。 人们盲目从先进的视网膜疾病丧失了大部分或全部的光感受器。
大多数视网膜假体技术,包括斯二世和阿尔法IMS,使用摄像头捕捉图像。 一组电极,毗邻视网膜植入,然后把图像转换成电信号,被发送到大脑,他们解释为愿景。
OUReP简单得多。 没有相机或电极,它不需要一个电流,通常需要一个外部电源。 相反,电影上的染料捕捉光线进入眼睛和刺激视网膜神经元生存,包括神经节和双相细胞,将视觉信息发送回大脑。
行长松尾,医学博士 博士项目的首席研究员说,植入视网膜下的OUReP应该相对简单的人类。 “表可以植入视网膜下空间,用手术方法建立了20多年前,”他解释说。 “因此,植入过程应该施行视网膜手术技术上可行”。
他补充说,假的聚乙烯薄膜已经使用在其他医疗植入物对人类安全,和染料没有显示任何毒性测试到目前为止。
除了保护视力,OUReP似乎减少损失啮齿动物的视网膜细胞,这表明染料可能会保护。 然而,研究人员警告说,还需要更多的研究来更好的理解效果。
“这种方法的简单性是很有吸引力的。 更少的组件意味着减少失败的风险和并发症,”斯蒂芬·罗斯博士说,研究总监基金会战斗失明。 ”也就是说,我们需要看看冈山假肢可以恢复有意义的视觉在人类。 这是底线。”

雪山飞狐

这篇文章是3月17发表在美国抗盲基金会的网站上的.

文章意思是在今年下半年会进行人体试验..这种简单的视网膜假体不用复杂摄像头和电极.而是通过涂有染料的的聚乙烯薄膜植入到视网膜下.通过染料捕捉光线和刺激视网膜神经元生存,包括神经节和双极细胞,将视觉信息发送回大脑。以改善视功能.专家还说这种聚乙烯薄膜和染料已经用在其他医学领域到目前为止没有发现任何毒副作用..专家还说这种方法的简单性是很有吸引力的。 更少的组件意味着减少失败的风险和并发症,希望这种视网膜假体可以明显提高视力.

月亮男孩

看看人家日本！

朝阳7945

希望能顺利研究成功！

福娃晶晶

谢谢飞狐带来的好消息！

BOBOm

谢谢飞狐给我们带来更详细的报道，期待实验成功！期待效果明显！

凤凰涅盘

感谢飞狐分享!