Healthy, Happy Living May Slow Retinal Degeneration
April 13, 2011 – Italian researchers have shown that mice with retinitis pigmemtosa raised in an enriched environment for one year had slower retinal degeneration than mice reared in a typical laboratory setting. The mice living in the enriched conditions had twice as many cone cells, the cells that provide central, color and detailed vision, and the cones were healthier. The scientists believe that these study results can be translated to humans.
Environmental enrichment for the mice included larger cages, running wheels, nesting material and companionship from “helper” female mice in addition to their biological mothers. The mice were also given objects that were changed twice a week to stimulate curiosity and exploration.
The investigators believe that exercise, stimulation, social activity and reduction in stress lead to an increase in the production of neurotrophic factors, proteins that keep cells of the brain, nervous system and retina healthy.
The research team included Drs. Ilaria Barone and Enrica Strettoi of the Italian National Research Council, CNR-Neuroscience Institute, Pisa, Italy; and Elena Novelli of the GB-Bietti Foundation for Ophthalmology, Rome, Italy.
They will present a poster on their findings at the annual meeting of the Association for Research in Vision and Ophthalmology in Ft. Lauderdale on Monday May 7, 2012, from 3:45 to 5:30 p.m.
2011年4月13日 - 意大利研究人员已经证明，在丰富的环境中提出的一年小鼠视网膜pigmemtosa速度比在一个典型的实验室环境中饲养的小鼠视网膜变性。许多视锥细胞，提供中央，颜色和详细的视力，视锥细胞，细胞健康，生活在富氧条件的小鼠的两倍。科学家们认为，这些研究成果可以转化为人类。
环境富集的小鼠，包括更大的笼子里，运行车轮，筑巢材料和“帮手”，除了其生母的雌性小鼠的陪伴。也给小鼠，每周更换两次，以刺激好奇心和探索的对象。
研究者认为，演习，刺激，社交活动和减少应力铅，增加生产中的神经营养因子，蛋白质，保持细胞的大脑，神经系统和视网膜的健康。
该研究小组成员包括博士。 ilaria巴罗内和Enrica意大利国家研究理事会，中国北车神经科学研究所，意大利比萨Strettoi和Elena诺维利GB Bietti基金会的眼科，罗马，意大利。
在尺在视觉与眼科研究协会的年度会议上，他们将介绍他们的研究成果海报。劳德代尔于2012年5月7日（星期一），从3时45分至下午5:30 |
